A Voxel-Based Monte Carlo Model of Drug Release from Bulk Eroding Nanoparticles
نویسندگان
چکیده
منابع مشابه
A voxel-based Monte Carlo model of drug release from bulk eroding nanoparticles.
The use of polymeric nanoparticles as drug delivery devices is becoming increasingly prevalent in a variety of therapeutic applications. Despite their widespread clinical use, the factors influencing the release profiles of nanoparticle-encapsulated drugs are still not quantitatively understood. We present here a new, semi-empirical model of drug release from polymeric nanoparticles using a for...
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Mechanically robust implants are being used in many different parts of the body for various applications in orthopedics, cardiovascular stents, and defibrillators. However, there are numerous problems to overcome, such as reducing infections, enhancing implant bonding, and preventing restenosis in cardiovascular stents, among others. A central strategy is to incorporate therapeutic agents that ...
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Background: Most preclinical studies are carried out on mice. For internal dose assessment of a mouse, specific absorbed fraction (SAF) values play an important role. In most studies, SAF values are estimated using older standard human organ compositions and values for limited source target pairs.Objective: SAF values for monoenergetic photons of energies 15, 50, 100, 500, 1000 and 4000 keV...
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PURPOSE Comparative drug release kinetics from nanoparticles was carried out using conventional and our novel models with the aim of finding a general model applicable to multi mechanistic release. Theoretical justification for the two best general models was also provided for the first time. METHODS Ten conventional models and three models developed in our laboratory were applied to release ...
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ژورنال
عنوان ژورنال: Journal of Nanoscience and Nanotechnology
سال: 2010
ISSN: 1533-4880
DOI: 10.1166/jnn.2010.2456